Muscle-bone interactions in dystrophin-deficient and myostatin-deficient mice.

  title={Muscle-bone interactions in dystrophin-deficient and myostatin-deficient mice.},
  author={Eric Montgomery and Catherine Pennington and Carlos M. Isales and Mark W Hamrick},
  journal={The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology},
  volume={286 1},
We have investigated muscle-bone interactions using two mouse mutants that are known to differ from normal mice in skeletal muscle growth and development: mice lacking myostatin (GDF8) and mice lacking dystrophin (mdx). Myostatin-deficient mice show increased muscle size and strength compared to normal mice, whereas the mdx mouse is a well-established animal model for Duchenne muscular dystrophy. The mdx mice have significantly larger hindlimb muscles than controls, and histological sections of… CONTINUE READING


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