Muscle as an endocrine organ: focus on muscle-derived interleukin-6.

@article{Pedersen2008MuscleAA,
  title={Muscle as an endocrine organ: focus on muscle-derived interleukin-6.},
  author={B. Pedersen and M. Febbraio},
  journal={Physiological reviews},
  year={2008},
  volume={88 4},
  pages={
          1379-406
        }
}
  • B. Pedersen, M. Febbraio
  • Published 2008
  • Biology, Medicine
  • Physiological reviews
  • Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been suggested that cytokines and other peptides that are produced, expressed, and released by muscle fibers and exert paracrine, autocrine, or endocrine effects should be classified as "myokines." Recent research demonstrates that skeletal muscles can produce and express cytokines belonging to distinctly different families. However, the first identified and most studied myokine is the gp130 receptor cytokine… CONTINUE READING
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    References

    SHOWING 1-10 OF 422 REFERENCES
    Signaling pathways for IL-6 within skeletal muscle.
    • M. Febbraio
    • Biology, Medicine
    • Exercise immunology review
    • 2003
    • 14
    The role of IL-6 in exercise-induced immune changes and metabolism.
    • 86
    Beneficial health effects of exercise--the role of IL-6 as a myokine.
    • 264
    Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
    • M. Febbraio, B. Pedersen
    • Biology, Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 2002
    • 797
    • PDF
    Role of myokines in exercise and metabolism.
    • 553
    • PDF
    The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor?
    • 240
    • PDF
    THIS ARTICLE HAS BEEN RETRACTED Exercise induces interleukin‐8 expression in human skeletal muscle
    • 128
    Interleukin-6 in acute exercise and training: what is the biological relevance?
    • 612
    • PDF
    Interleukins and exercise
    • M. Gleeson
    • Biology, Medicine
    • The Journal of physiology
    • 2000
    • 106