Muscle as an endocrine organ: focus on muscle-derived interleukin-6.

  title={Muscle as an endocrine organ: focus on muscle-derived interleukin-6.},
  author={B. Pedersen and M. Febbraio},
  journal={Physiological reviews},
  volume={88 4},
  • B. Pedersen, M. Febbraio
  • Published 2008
  • Biology, Medicine
  • Physiological reviews
  • Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been suggested that cytokines and other peptides that are produced, expressed, and released by muscle fibers and exert paracrine, autocrine, or endocrine effects should be classified as "myokines." Recent research demonstrates that skeletal muscles can produce and express cytokines belonging to distinctly different families. However, the first identified and most studied myokine is the gp130 receptor cytokine… CONTINUE READING
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