Muscle apoptosis in humans occurs in normal and denervated muscle, but not in myotonic dystrophy, dystrophinopathies or inflammatory disease

@article{Migheli1997MuscleAI,
  title={Muscle apoptosis in humans occurs in normal and denervated muscle, but not in myotonic dystrophy, dystrophinopathies or inflammatory disease},
  author={Antonio Migheli and Tiziana Mongini and Carlo Doriguzzi and Loredana Chiad{\`o}-Piat and Roberto Piva and Isabella Ugo and L. Palmucci},
  journal={Neurogenetics},
  year={1997},
  volume={1},
  pages={81-87}
}
Recent data suggest that death of muscle cells during development and in selected pathological conditions occurs via apoptosis. We investigated the occurrence of apoptosis in normal and pathological human skeletal muscle, using in situ end-labeling (ISEL) to detect DAN fragmentation, and immunohistochemistry for the expression of tissue transglutaminase and interleukin-1β-converting enzyme (ICE)-like proteases. In normal subjects, apoptotic myonuclei were occasionally observed as evidence of… CONTINUE READING
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