Muscle and motor-skill dysfunction in a K+ channel-deficient mouse are not due to altered muscle excitability or fiber type but depend on the genetic background

@article{Sanchez2000MuscleAM,
  title={Muscle and motor-skill dysfunction in a K+ channel-deficient mouse are not due to altered muscle excitability or fiber type but depend on the genetic background},
  author={Jorge A Ortiz Sanchez and Chi Shun Ho and Donna M. Vaughan and Mar{\'i}a del Carmen Garc{\'i}a and Robert W. Grange and Rolf H. Joho},
  journal={Pfl{\"u}gers Archiv},
  year={2000},
  volume={440},
  pages={34-41}
}
The voltage-gated K+ channel Kv3.1 is expressed in skeletal muscle and in GABAergic interneurons in the central nervous system. Hence, the absence of Kv3.1 K+ channels may lead to a phenotype of myogenic or neurogenic origin, or both. Kv3.1-deficient (Kv3.1–/–) 129/Sv mice display altered contractile properties of their skeletal muscles and show poor performance on a rotating rod. In contrast, Kv3.1–/– mice on the (129/Sv×C57BL/6)F1 background display normal muscle properties and perform like… CONTINUE READING
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