Muscle and bone follow similar temporal patterns of recovery from muscle-induced disuse due to botulinum toxin injection.

@article{Manske2010MuscleAB,
  title={Muscle and bone follow similar temporal patterns of recovery from muscle-induced disuse due to botulinum toxin injection.},
  author={Sarah Lynn Manske and Steven K. Boyd and Ronald F. Zernicke},
  journal={Bone},
  year={2010},
  volume={46 1},
  pages={24-31}
}
If muscle force is a primary source for triggering bone adaptation, with disuse and reloading, bone changes should follow muscle changes. We examined the timing and magnitude of changes in muscle cross-sectional area (MCSA) and bone architecture in response to muscle inactivity following botulinum toxin (BTX) injection. We hypothesized that MCSA would return to baseline levels sooner than bone properties following BTX injection. Female BALB mice (15 weeks old) were injected with 20 muL of BTX… CONTINUE READING

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