Muscle Fatigue from the Perspective of a Single Crossbridge.

@article{Debold2016MuscleFF,
  title={Muscle Fatigue from the Perspective of a Single Crossbridge.},
  author={Edward P. Debold and Robert H Fitts and Christopher W Sundberg and Thomas M. Nosek},
  journal={Medicine and science in sports and exercise},
  year={2016},
  volume={48 11},
  pages={2270-2280}
}
The repeated intense stimulation of skeletal muscle rapidly decreases its force- and motion-generating capacity. This type of fatigue can be temporally correlated with the accumulation of metabolic by-products, including phosphate (Pi) and protons (H). Experiments on skinned single muscle fibers demonstrate that elevated concentrations of these ions can reduce maximal isometric force, unloaded shortening velocity, and peak power, providing strong evidence for a causative role in the fatigue… CONTINUE READING
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