Muscle Cells Provide Instructions for Planarian Regeneration
@article{Witchley2013MuscleCP, title={Muscle Cells Provide Instructions for Planarian Regeneration}, author={Jessica N. Witchley and Mirjam Mayer and D. E. Wagner and Jared H. Owen and P. Reddien}, journal={Cell reports}, year={2013}, volume={4}, pages={633 - 641} }
Regeneration requires both potential and instructions for tissue replacement. In planarians, pluripotent stem cells have the potential to produce all new tissue. The identities of the cells that provide regeneration instructions are unknown. Here, we report that position control genes (PCGs) that control regeneration and tissue turnover are expressed in a subepidermal layer of nonneoblast cells. These subepidermal cells coexpress many PCGs. We propose that these subepidermal cells provide a… CONTINUE READING
Paper Mentions
150 Citations
Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians
- Biology, Medicine
- Development
- 2017
- 19
- Highly Influenced
- PDF
Planarian Body-Wall Muscle: Regeneration and Function beyond a Simple Skeletal Support
- Biology, Medicine
- Front. Cell Dev. Biol.
- 2016
- 29
- Highly Influenced
- PDF
Muscle functions as a connective tissue and source of extracellular matrix in planarians
- Biology, Medicine
- Nature Communications
- 2019
- 14
- PDF
Planarian stem cells sense the identity of missing tissues to launch targeted regeneration
- Biology
- 2020
- 1
- PDF
Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning
- Biology, Medicine
- Nature Communications
- 2017
- 18
- PDF
Self-organization and progenitor targeting generate stable patterns in planarian regeneration
- Biology, Medicine
- Science
- 2018
- 18
- PDF
Orthogonal muscle fibers have different instructive roles in planarian regeneration
- Biology, Medicine
- Nature
- 2017
- 45
Planarian Epidermal Stem Cells Respond to Positional Cues to Promote Cell-Type Diversity.
- Biology, Medicine
- Developmental cell
- 2017
- 43
Cellular and Molecular Responses Unique to Major Injury Are Dispensable for Planarian Regeneration.
- Biology, Medicine
- Cell reports
- 2018
- 12
References
SHOWING 1-10 OF 70 REFERENCES
Fundamentals of planarian regeneration.
- Biology, Medicine
- Annual review of cell and developmental biology
- 2004
- 765
- PDF
Planarian regeneration involves distinct stem cell responses to wounds and tissue absence.
- Biology, Medicine
- Developmental biology
- 2010
- 231
- PDF
Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration
- Biology, Medicine
- Science
- 2011
- 465
- PDF
Myocyte differentiation and body wall muscle regeneration in the planarian Girardia tigrina
- Biology, Medicine
- Development Genes and Evolution
- 1997
- 56
Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea.
- Biology, Medicine
- Cell stem cell
- 2008
- 322
- PDF
A molecular wound response program associated with regeneration initiation in planarians.
- Biology, Medicine
- Genes & development
- 2012
- 171
- Highly Influential
- PDF
Constitutive gene expression and the specification of tissue identity in adult planarian biology.
- Biology, Medicine
- Trends in genetics : TIG
- 2011
- 91
- PDF
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.
- Biology, Medicine
- Developmental cell
- 2005
- 383
- PDF
Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis.
- Biology, Medicine
- Cell stem cell
- 2012
- 137