Muscle Cells Provide Instructions for Planarian Regeneration

  title={Muscle Cells Provide Instructions for Planarian Regeneration},
  author={Jessica N. Witchley and Mirjam Mayer and D. E. Wagner and Jared H. Owen and P. Reddien},
  journal={Cell reports},
  pages={633 - 641}
  • Jessica N. Witchley, Mirjam Mayer, +2 authors P. Reddien
  • Published 2013
  • Biology, Medicine
  • Cell reports
  • Regeneration requires both potential and instructions for tissue replacement. In planarians, pluripotent stem cells have the potential to produce all new tissue. The identities of the cells that provide regeneration instructions are unknown. Here, we report that position control genes (PCGs) that control regeneration and tissue turnover are expressed in a subepidermal layer of nonneoblast cells. These subepidermal cells coexpress many PCGs. We propose that these subepidermal cells provide a… CONTINUE READING
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