Muscle Carnosine Metabolism and β-Alanine Supplementation in Relation to Exercise and Training

@article{Derave2010MuscleCM,
  title={Muscle Carnosine Metabolism and $\beta$-Alanine Supplementation in Relation to Exercise and Training},
  author={Wim Derave and Inge Everaert and Sam Beeckman and Audrey Baguet},
  journal={Sports Medicine},
  year={2010},
  volume={40},
  pages={247-263}
}
Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and β-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase. Recent studies have shown that the chronic oral ingestion of β-alanine can substantially elevate (up to 80%) the carnosine content of human skeletal muscle. Interestingly, muscle carnosine loading leads to improved performance in high-intensity… 

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