Muscle Carnosine Metabolism and β-Alanine Supplementation in Relation to Exercise and Training

@article{Derave2010MuscleCM,
  title={Muscle Carnosine Metabolism and $\beta$-Alanine Supplementation in Relation to Exercise and Training},
  author={W. Derave and I. Everaert and S. Beeckman and A. Baguet},
  journal={Sports Medicine},
  year={2010},
  volume={40},
  pages={247-263}
}
Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and β-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase. Recent studies have shown that the chronic oral ingestion of β-alanine can substantially elevate (up to 80%) the carnosine content of human skeletal muscle. Interestingly, muscle carnosine loading leads to improved performance in high-intensity… Expand
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References

SHOWING 1-10 OF 125 REFERENCES
Carnosine loading and washout in human skeletal muscles.
TLDR
It can be concluded that carnosine is a stable compound in human skeletal muscle, confirming the absence of carnosinase in myocytes, and shows that washout periods for crossover designs in supplementation studies for muscle metabolites may sometimes require months rather than weeks. Expand
Physiological role of carnosine in contracting muscle.
TLDR
The effect of carnosine on overcoming muscle fatigue appears to be related to its ability to buffer the increased H(+) concentration following high-intensity work. Expand
High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting.
TLDR
The results indicated that the carnosine concentration could be an important factor in determining the high-intensity exercise performance. Expand
Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity
TLDR
The increase in TWD with supplementation followed the increase in muscle carnosine, which was significantly increased by +58.8% and +80.1% after 4 and 10 wks β-alanine supplementation. Expand
beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters.
TLDR
Proton MRS can be used to noninvasively quantify human muscle Carnosine content and muscle carnosine is increased by oral beta-alanine supplementation in sprint-trained athletes; carnosinesine loading slightly but significantly attenuated fatigue in repeated bouts of exhaustive dynamic contractions; and the increase in muscle Carnival did not improve isometric endurance or 400-m race time. Expand
THE CARNOSINE CONTENT OF VASTUS LATERALIS IS ELEVATED IN RESISTANCE‐TRAINED BODYBUILDERS
TLDR
The carnosine contents measured are the highest recorded in human muscle and represent a 20% contribution to muscle buffering capacity, and Taurine was 38% lower in bodybuilders, though the difference was not significant. Expand
The effects of 10 weeks of resistance training combined with β-alanine supplementation on whole body strength, force production, muscular endurance and body composition
TLDR
In conclusion, 10 weeks of resistance training alone did not change M-[Carn], and the aim of this investigation was to investigate if increased M:[Carn] brought about through β-ala supplementation had a positive effect on training responses. Expand
The Effect of Sprint Training on Skeletal Muscle Carnosine in Humans
TLDR
The results suggest that the increases in skeletal muscle carnosine concentration following sprint training may be associated with the increase in sustainability of high power during 30-s maximal cycle ergometer sprinting. Expand
β-Alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise
TLDR
Results indicate that chronic β-alanine supplementation, which presumably increased muscle carnosine content, can attenuate the fall in blood pH during high-intensity exercise. Expand
Creatine supplementation augments skeletal muscle carnosine content in senescence-accelerated mice (SAMP8).
TLDR
It is concluded that skeletal muscle tissue exhibits a significant decline in HCD content at old age, and oral creatine supplementation is able to transiently but potently increase muscle carnosine and anserine content, which coincides with improved resistance to contractile fatigue. Expand
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