Muscle CD31(-) CD45(-) side population cells promote muscle regeneration by stimulating proliferation and migration of myoblasts.

@article{Motohashi2008MuscleCC,
  title={Muscle CD31(-) CD45(-) side population cells promote muscle regeneration by stimulating proliferation and migration of myoblasts.},
  author={Norio Motohashi and Akiyoshi Uezumi and Erica Yada and So-Ichiro Fukada and Kazuhiro Fukushima and Kazuhiko Imaizumi and Yuko Miyagoe-Suzuki and Shin'ichi Takeda},
  journal={The American journal of pathology},
  year={2008},
  volume={173 3},
  pages={781-91}
}
CD31(-) CD45(-) side population (SP) cells are a minor SP subfraction that have mesenchymal stem cell-like properties in uninjured skeletal muscle but that can expand on muscle injury. To clarify the role of these SP cells in muscle regeneration, we injected green fluorescent protein (GFP)-positive myoblasts with or without CD31(-) CD45(-) SP cells into the tibialis anterior muscles of immunodeficient NOD/scid mice or dystrophin-deficient mdx mice. More GFP-positive fibers were formed after co… CONTINUE READING
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