Muscimol as an Ionotropic GABA Receptor Agonist

  title={Muscimol as an Ionotropic GABA Receptor Agonist},
  author={Graham A. R. Johnston},
  journal={Neurochemical Research},
  • G. Johnston
  • Published 29 January 2014
  • Biology, Chemistry
  • Neurochemical Research
Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe GABA receptors and was the lead compound in the development of a range of GABAergic agents including… 

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