Muscarinic supersensitivity in the rat urinary bladder after capsaicin pretreatment.

  title={Muscarinic supersensitivity in the rat urinary bladder after capsaicin pretreatment.},
  author={Agnes Malmgren and Eva Ekblad and Frank Sundler and Karl Erik Andersson and P. O. Andersson},
  journal={Acta physiologica Scandinavica},
  volume={138 3},
The effects of capsaicin on urinary bladder function have been investigated in adult rats. Ten days after capsaicin treatment immunocytochemical investigations showed a nearly complete disappearance of substance P (SP) and calcitonin gene-related peptide (CGRP) in all parts of the bladder. Recordings of micturition patterns and cytometrical investigations in conscious animals revealed no functional effects of capsaicin treatment. In-vitro experiments showed that the contractile response to… 

Contractility of urinary bladder and vas deferens after sensory denervation by capsaicin treatment of newborn rats

Chronic capsaicin treatment increases the amplitude of contractions of the rat urinary bladder, an effect which preferentially involves the cholinergic component of the response; since the response to carbachol is unaffected, the change involves prejunctional mechanisms.

Effects of denervation on muscarinic receptors in the rat bladder.

Muscarinic receptors were localized over the smooth muscle of the rat bladder and were increased after post-ganglionic denervation, which may be responsible for the increased sensitivity to muscarinic agonists reported to occur after bladder denervation.

Effects of age and streptozotocin-induced diabetes on contents and effects of substance P and vasoactive intestinal polypeptide in the lower urinary tract of the rat.

The bladder contractile response to substance P was similar in all groups of animals and vasoactive intestinal polypeptide was found to be devoid of contractile or relaxatory effects in the rat bladder, and changes were seen in both the bladder and the urethra and were similar in diabetic and normal animals.

Muscarinic Receptor Subtypes in the Lower Urinary Tract

Signalling mechanisms, expression and functional effects of muscarinic receptors in the lower urinary tract are described and their roles in physiological and pathophysiological conditions, as well as clinical implications of the occurrence of different mus carinic receptors, are discussed.


The present study provides further evidence that augmentation cystoplasty with the BAMG leads to functional regeneration of the rat bladder detrusor smooth muscle.

Autonomous contractile activity in the isolated rat bladder is modulated by a TRPV1 dependent mechanism

To eliminate the effects of RTX on spinal and central neural circuits, this work investigated autonomous contractility in normal and neurogenic rat bladders after treatment with RTX.

TRPV1 is involved in stretch‐evoked contractile changes in the rat autonomous bladder model: a study with piperine, a new TRPV1 agonist

This study looked at PIP‐effects on autonomous bladder contractile activity, with particular interest for its selectivity for the transient receptor potential channel 1 (TRPV1) receptor, and studied the role of TRpV1 in volume‐induced contractile changes using selective and non‐selective TRPV 1 antagonists.



Functional evidence for the existence of a capsaicin‐sensitive innervation in the rat urinary bladder

Evidence is provided that a capsaicin‐sensitive innervation exists in the rat urinary bladder which undergoes a postnatal development at end organ level and is proved to be neurogenic.

Systemic capsaicin treatment impairs the micturition reflex in the rat

It is concluded that all primary afferent fibres mediating the sensation of a full bladder are capsaicin‐sensitive and an additional effect of Capsaicin on renal mechanisms cannot be excluded.

Substance P and somatostatin and excitatory neurotransmission in rabbit urinary bladder.

Neither SS nor SP is the mediator of excitatory non-cholinergic, non-adrenergic activation of rabbit urinary bladder, and a role as local modulators of neuromuscular transmission cannot be excluded.

Contractile effects of some polypeptides on the isolated urinary bladder of guinea-pig, rabbit, and rat.

It is concluded that SP and E cause contraction of detrusor by a direct effect on the smooth muscle cells, and that this response is dependent on the extracellular calcium concentration.

Vascular permeability changes and smooth muscle contraction in relation to capsaicin-sensitive substance P afferents in the guinea-pig.

In conclusion, neurogenic inflammation occurs in several organs with a highly region-specific distribution, which is accompanied by the presence of capsaicin-sensitive SP neurons, which causes smooth muscle contraction in several visceral organs.