Muscarinic supersensitivity in the rat urinary bladder after capsaicin pretreatment.

@article{Malmgren1990MuscarinicSI,
  title={Muscarinic supersensitivity in the rat urinary bladder after capsaicin pretreatment.},
  author={Agnes Malmgren and Eva Ekblad and Frank Sundler and Karl Erik Andersson and P. O. Andersson},
  journal={Acta physiologica Scandinavica},
  year={1990},
  volume={138 3},
  pages={
          377-87
        }
}
The effects of capsaicin on urinary bladder function have been investigated in adult rats. Ten days after capsaicin treatment immunocytochemical investigations showed a nearly complete disappearance of substance P (SP) and calcitonin gene-related peptide (CGRP) in all parts of the bladder. Recordings of micturition patterns and cytometrical investigations in conscious animals revealed no functional effects of capsaicin treatment. In-vitro experiments showed that the contractile response to… 

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Functional evidence for the existence of a capsaicin‐sensitive innervation in the rat urinary bladder

Evidence is provided that a capsaicin‐sensitive innervation exists in the rat urinary bladder which undergoes a postnatal development at end organ level and is proved to be neurogenic.

Systemic capsaicin treatment impairs the micturition reflex in the rat

It is concluded that all primary afferent fibres mediating the sensation of a full bladder are capsaicin‐sensitive and an additional effect of Capsaicin on renal mechanisms cannot be excluded.

Substance P and somatostatin and excitatory neurotransmission in rabbit urinary bladder.

Neither SS nor SP is the mediator of excitatory non-cholinergic, non-adrenergic activation of rabbit urinary bladder, and a role as local modulators of neuromuscular transmission cannot be excluded.

Contractile effects of some polypeptides on the isolated urinary bladder of guinea-pig, rabbit, and rat.

It is concluded that SP and E cause contraction of detrusor by a direct effect on the smooth muscle cells, and that this response is dependent on the extracellular calcium concentration.

Vascular permeability changes and smooth muscle contraction in relation to capsaicin-sensitive substance P afferents in the guinea-pig.

In conclusion, neurogenic inflammation occurs in several organs with a highly region-specific distribution, which is accompanied by the presence of capsaicin-sensitive SP neurons, which causes smooth muscle contraction in several visceral organs.