Muscarinic receptors modulating acetylcholine release from insect synaptosomes.

  title={Muscarinic receptors modulating acetylcholine release from insect synaptosomes.},
  author={M. Knipper and Heinz Breer},
  journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
  volume={93 2},
1. Cholinergic synapses in the central nervous system of insects contain inhibitory muscarinic receptors whose stimulation by agonists leads to a diminished output of acetylcholine; antagonists, like atropine, facilitate acetylcholine release. 2. The receptors involved appear to be of the M2-subtype. Upon activation of presynaptic receptors a significant reduction of the intrasynaptosomal cyclic AMP level as well as a significantly increased membrane potential was observed. 3. The observed… CONTINUE READING