Muscarinic receptors involved in the subthreshold cholinergic actions of neostriatal spiny neurons.


Administration of the peptide MT-1 (48 nM), a selective agonist of muscarinic M(1)-type receptors, mimicked the subthreshold actions of muscarine (1 microM) on neostriatal neurons, i.e., it produced a reduction in subthreshold inward rectification leading to an enhancement in input resistance (R(N)) and evoked discharge. In all recorded cells, MT-1 effects… (More)


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