Muscarinic receptors and control of airway smooth muscle.

  title={Muscarinic receptors and control of airway smooth muscle.},
  author={Allison D Fryer and David B Jacoby},
  journal={American journal of respiratory and critical care medicine},
  volume={158 5 Pt 3},
Contraction of airway smooth muscle is mediated by M3 muscarinic receptors on the airway smooth muscle. However, there is no evidence suggesting that hyperresponsiveness results from any alterations in function of these M3 muscarinic receptors. In contrast, there is clearly increased release of the neurotransmitter acetylcholine in animal models of hyperactivity and in asthma. Release of acetylcholine is controlled by inhibitory M2 muscarinic receptors, and it appears that it is these M2… CONTINUE READING
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