Muscarinic receptors: relationships among phosphoinositide breakdown, adenylate cyclase inhibition, in vitro detrusor muscle contractions and in vivo cystometrogram studies in guinea pig bladder.

@article{NoronhaBlob1989MuscarinicRR,
  title={Muscarinic receptors: relationships among phosphoinositide breakdown, adenylate cyclase inhibition, in vitro detrusor muscle contractions and in vivo cystometrogram studies in guinea pig bladder.},
  author={Lalita Noronha-Blob and Val J. Lowe and Alice C Patton and Brendan J. Canning and Dennis Costello and W. J. Kinnier},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={249 3},
  pages={843-51}
}
The relationships between activation of muscarinic receptors in guinea pig bladder measured as carbachol-stimulated inositol phosphate (IP) accumulation, oxotremorine-induced adenylate cyclase (AC) inhibition and bladder detrusor smooth muscle contraction determined in vitro as well as in vivo in the slow filling cystometrogram (CMG), were analyzed from the potencies of a number of muscarinic antagonists to block these responses. Significant positive linear correlations were found among the… CONTINUE READING

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