Muscarinic receptor subtypes on rat pancreatic acini: secretion and binding studies.

  title={Muscarinic receptor subtypes on rat pancreatic acini: secretion and binding studies.},
  author={Donald Louie and Chung Owyang},
  journal={The American journal of physiology},
  volume={251 2 Pt 1},
Characterization of muscarinic receptor subtypes on rat pancreatic acinar cells was examined by using specific muscarinic receptor antagonists to study amylase secretion and binding of [N-methyl-3H]scopolamine ([3H]NMS). Rat pancreatic acini were dispersed in HEPES-Ringer buffer and incubated with acetylcholine +/- 4-diphenylacetoxy-N-methylpiperadine-methiodide (4-DAMP, a specific M2 muscarinic receptor antagonist) or +/- pirenzepine (a specific M1 muscarinic receptor antagonist). 4-DAMP (10… CONTINUE READING


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