Muscarinic receptor subtypes in human neuroblastoma cell lines SH-SY5Y and IMR-32 as determined by receptor binding, Ca++ mobilization and northern blotting.

Abstract

Muscarinic receptor subtypes in neuroblastoma cell lines IMR-32 and SH-SY5Y were determined with receptor binding, Ca++ mobilization and Northern blotting. Displacement of [3H]NMS with pirenzepine in IMR-32 cells revealed apparent binding sites with Kd values of 5 (41%) and 237 nM (59%). With 4-diphenylacetoxy-N-metylpiperidine metiodid, a similar… (More)

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@article{Kukkonen1992MuscarinicRS, title={Muscarinic receptor subtypes in human neuroblastoma cell lines SH-SY5Y and IMR-32 as determined by receptor binding, Ca++ mobilization and northern blotting.}, author={Jari Kukkonen and P{\"a}ivi M. Ojala and Johnny N{\"a}sman and Harri H{\"a}m{\"a}l{\"a}inen and J. K. Heikkil{\"a} and Karl E {\AA}kerman}, journal={The Journal of pharmacology and experimental therapeutics}, year={1992}, volume={263 3}, pages={1487-93} }