Muscarinic receptor subtypes and receptor-coupled phosphatidylinositol hydrolysis in rat bladder smooth muscle.

@article{Mimata1997MuscarinicRS,
  title={Muscarinic receptor subtypes and receptor-coupled phosphatidylinositol hydrolysis in rat bladder smooth muscle.},
  author={Hiromitsu Mimata and Yukari Nomura and Akio Emoto and Jamshid Latifpour and Matthew A. Wheeler and Robert M. Weiss},
  journal={International journal of urology : official journal of the Japanese Urological Association},
  year={1997},
  volume={4 6},
  pages={591-6}
}
BACKGROUND The purpose of this study was to evaluate the muscarinic receptor subtypes expressed in rat bladder smooth muscle and characterize the muscarinic receptor-coupled phosphatidylinositol (PI) hydrolysis in order to clarify the first step of bladder smooth muscle contraction. METHODS Expressions of mRNAs of muscarinic receptor subtypes were examined by Northern blot analysis. Changes in the mass of inositol 1,4,5-trisphosphate (IP3) and the inhibitory effects of muscarinic subtype… CONTINUE READING

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