Muscarinic receptor regulation of cardiac adenylate cyclase activity.

  title={Muscarinic receptor regulation of cardiac adenylate cyclase activity.},
  author={J. W. Fleming and R A Strawbridge and August M. Watanabe},
  journal={Journal of molecular and cellular cardiology},
  volume={19 1},
Stimulation and inhibition of adenylate cyclase activity are mediated by the guanine nucleotide regulatory proteins Gs and Gi, respectively. Two general mechanisms have been proposed for the inhibition of activated adenylate cyclase: direct inhibition of the catalyst by Gi, and indirect inhibition of the activated catalyst mediated by Gi inhibition of Gs. We have assessed direct inhibition of adenylate cyclase by evaluating the ability of Gpp(NH)p to inhibit the forskolin-stimulated enzyme in… CONTINUE READING
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