Muscarinic receptor density in the rat urinary bladder after denervation, hypertrophy and urinary diversion.

@article{Nilvebrant1986MuscarinicRD,
  title={Muscarinic receptor density in the rat urinary bladder after denervation, hypertrophy and urinary diversion.},
  author={Lisbeth Nilvebrant and J{\"o}rgen Ekstr{\"o}m and L. -H. Malmberg},
  journal={Acta pharmacologica et toxicologica},
  year={1986},
  volume={59 4},
  pages={306-14}
}
Parasympathetic denervation of the urinary bladder results in supersensitivity to muscarinic agonists and in bladder hypertrophy. In the present study, the effects of denervation on the muscarinic receptors in the rat bladder were investigated, using a receptor binding technique with (-)3H-QNB as radioligand. The density of muscarinic receptors was increased in denervated, hypertrophied bladders but it was decreased, below that in control bladders, when the development of hypertrophy was… CONTINUE READING