Muscarinic receptor activation of arachidonate-mediated Ca2+ entry in HEK293 cells is independent of phospholipase C.

@article{Shuttleworth1998MuscarinicRA,
  title={Muscarinic receptor activation of arachidonate-mediated Ca2+ entry in HEK293 cells is independent of phospholipase C.},
  author={Trevor J. Shuttleworth and Jill L. Thompson},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 49},
  pages={32636-43}
}
Receptor-enhanced entry of Ca2+ in non-excitable cells is generally ascribed to a capacitative mechanism in which the activation of the entry pathway is specifically dependent on the emptying of agonist-sensitive intracellular Ca2+ stores. Although such entry can be clearly demonstrated under conditions of maximal or near-maximal stimulation, it is uncertain whether such a mechanism can operate during the oscillatory [Ca2+]i signals that are frequently seen following stimulation with low… CONTINUE READING

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