Muscarinic receptor activation determines the effects of store-operated Ca(2+)-entry on excitability and energy metabolism in pyramidal neurons.

@article{Kann2012MuscarinicRA,
  title={Muscarinic receptor activation determines the effects of store-operated Ca(2+)-entry on excitability and energy metabolism in pyramidal neurons.},
  author={Oliver Kann and Nando Taubenberger and Christine Huchzermeyer and Ismini E Papageorgiou and Felix Benninger and Uwe F Heinemann and Richard Frank Kovacs},
  journal={Cell calcium},
  year={2012},
  volume={51 1},
  pages={
          40-50
        }
}
In various cell types, depletion of intracellular Ca(2+)-stores results in store-operated Ca(2+)-entry (SOCE) across the cellular membrane. However, the effects of SOCE on neuronal membrane excitability and mitochondrial functions in central neurons are not well defined. We investigated such cellular downstream effects in pyramidal neurons of rat organotypic hippocampal slice cultures by applying electrophysiological and fluorescence imaging techniques. We report that SOCE is associated with (i… CONTINUE READING
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