Muscarinic receptor-activated signal transduction pathways involved in the neuritogenic effect of astrocytes in hippocampal neurons.

@article{Guizzetti2011MuscarinicRS,
  title={Muscarinic receptor-activated signal transduction pathways involved in the neuritogenic effect of astrocytes in hippocampal neurons.},
  author={Marina Guizzetti and Nadia H. Moore and Kathryn L VanDemark and Gennaro Giordano and Lucio Guido Costa},
  journal={European journal of pharmacology},
  year={2011},
  volume={659 2-3},
  pages={102-7}
}
Astrocytes have been shown to release factors that affect various aspects of neuronal development. We have previously shown that the acetylcholine analog carbachol, by activating muscarinic M(3) receptors in rat astrocytes, increases their ability to promote neuritogenesis in hippocampal neurons. This effect was mediated by an increased expression and release by astrocytes of several permissive factors, a most relevant of which was fibronectin. In the present study we investigated the signal… CONTINUE READING