Muscarinic preferential M(1) receptor antagonists enhance the discriminative-stimulus effects of cocaine in rats.

@article{Tanda2007MuscarinicPM,
  title={Muscarinic preferential M(1) receptor antagonists enhance the discriminative-stimulus effects of cocaine in rats.},
  author={Gianluigi Tanda and Jonathan Katz},
  journal={Pharmacology, biochemistry, and behavior},
  year={2007},
  volume={87 4},
  pages={400-4}
}
Previous studies of benztropine analogues have found them to inhibit dopamine uptake like cocaine, but with less effectiveness than cocaine in producing behavioral effects related to drug abuse. Studies have assessed whether nonselective muscarinic antagonists decrease the effects of cocaine because many of the benztropine analogues are also muscarinic… CONTINUE READING