Muscarinic modulation of voltage-dependent Ca2+ channels in insulin-secreting HIT-T15 cells.

@article{Love1998MuscarinicMO,
  title={Muscarinic modulation of voltage-dependent Ca2+ channels in insulin-secreting HIT-T15 cells.},
  author={Jeffrey A. Love and N. Richards and Chung Owyang and David C. Dawson},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={1998},
  volume={274 2},
  pages={G397-G405}
}
Potentiation of insulin secretion from pancreatic β-cells by acetylcholine requires ongoing cyclic electrical activity initiated by other depolarizing secretagogues. Patch-clamp recordings in glucose-free solutions were made from the clonal β-cell line HIT-T15 to determine whether the muscarinic agonist bethanechol (BCh) modulated voltage-dependent Ca2+ channels independent of effects on membrane potential. Only high-threshold, dihydropyridine-sensitive (L-type) Ca2+ channels with a mean… CONTINUE READING
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