Muscarinic mechanisms of antipsychotic atypicality

@article{Bymaster2003MuscarinicMO,
  title={Muscarinic mechanisms of antipsychotic atypicality},
  author={Frank P. Bymaster and Christian C. Felder and Eleni T. Tzavara and G. Nomikos and David McKinzie},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2003},
  volume={27},
  pages={1125-1143}
}
  • F. Bymaster, C. Felder, D. McKinzie
  • Published 1 October 2003
  • Psychology, Medicine, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
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TLDR
It is suggested that muscarinic receptors and limbic brain regions such as hippocampus and amygdala might represent common targets that mediate beneficial clinical effects of antipsychotic drugs.
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TLDR
Preclinical and clinical data suggest that selective activation of the muscarinic cholinergic system may represent novel therapeutic mechanisms for the treatment of schizophrenia.
Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats
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The substantial occupancy of muscarinic receptors in the striatum and cortex by olanzapine may be an explanation for the low incidence and severity of extrapyramidal side effects of this antipsychotic drug.
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