Muscarinic mechanisms of antipsychotic atypicality

  title={Muscarinic mechanisms of antipsychotic atypicality},
  author={Frank P. Bymaster and Christian C. Felder and Eleni Th Tzavara and George G. Nomikos and David L. Mckinzie},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
The interactions of the atypical antipsychotic drugs (APD) clozapine, olanzapine, risperidone, quetiapine and ziprasidone with muscarinic receptors were reviewed. Only clozapine and olanzapine have marked affinity for muscarinic receptors in radioligand binding studies; however, the affinity of these compounds is considerably lower than classical muscarinic antagonists. Although functional assays in cell lines transfected with muscarinic receptors suggest that olanzapine and clozapine have weak… CONTINUE READING


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