Muscarinic mechanisms of antipsychotic atypicality

@article{Bymaster2003MuscarinicMO,
  title={Muscarinic mechanisms of antipsychotic atypicality},
  author={Frank P. Bymaster and Christian C. Felder and Eleni T. Tzavara and G. Nomikos and David McKinzie},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2003},
  volume={27},
  pages={1125-1143}
}
  • F. Bymaster, C. Felder, D. McKinzie
  • Published 1 October 2003
  • Psychology, Medicine, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
View on Elsevier
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136 Citations
Highly Influential Citations
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Background Citations
58
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136 Citations

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TLDR
Administration of NMDC reversed a striking hyperactive phenotype in the phospholipase C-&bgr;1 knockout mouse, whereas no significant effects were observed in wild-type animals, highlighting the potential role of muscarinic activity in the behavioural response to NDMC.
Chronic treatment with first or second generation antipsychotics in rodents: Effects on high affinity nicotinic and muscarinic acetylcholine receptors in the brain
Muscarinic mechanisms in psychotic disorders.
TLDR
It is proposed that an agonist with M(1) and M(4) interactions would effectively treat core symptom clusters associated with schizophrenia.
Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice
TLDR
It is suggested that disruption of the M5 receptor gene affected sensorimotor gating mechanisms, increased sensitivity to clozapine and to the psychostimulant effects of muscarinic antagonists without modifying the effect of dopaminergic drugs.
Effects of Typical and Atypical Antipsychotic Drugs on Rat Brain Muscarinic Receptors
TLDR
It is suggested that muscarinic receptors and limbic brain regions such as hippocampus and amygdala might represent common targets that mediate beneficial clinical effects of antipsychotic drugs.
Muscarinic agonists and antagonists in schizophrenia: recent therapeutic advances and future directions.
TLDR
Preclinical and clinical data suggest that selective activation of the muscarinic cholinergic system may represent novel therapeutic mechanisms for the treatment of schizophrenia.
Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences
Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats
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TLDR
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Xanomeline, an M1/M4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice
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