Muscarinic inhibition of two potassium currents in guinea-pig prevertebral neurons: Differentiation by extracellular cesium

@article{Coggan1994MuscarinicIO,
  title={Muscarinic inhibition of two potassium currents in guinea-pig prevertebral neurons: Differentiation by extracellular cesium},
  author={Jay S. Coggan and S L Purnyn and S R Knoper and David L. Kreulen},
  journal={Neuroscience},
  year={1994},
  volume={59},
  pages={349-361}
}
Muscarinic responses were studied in dissociated guinea-pig celiac ganglion neurons using the whole-cell voltage-clamp technique. Muscarine (0.025-1 mM; EC50 = 95 microM) administered to cells for 1.5 s evoked inward shifts in holding current in 53 of 74 cells. The amplitude of the inward current transients decreased with hyperpolarization and the null potential averaged -71 +/- 3.4 mV (n = 11). The currents that underlie the responses to muscarine were examined with hyperpolarizing voltage… CONTINUE READING

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