Muscarinic cholinergic receptors in the human spinal cord: differential localization of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding sites.

@article{Villiger1985MuscarinicCR,
  title={Muscarinic cholinergic receptors in the human spinal cord: differential localization of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding sites.},
  author={J W Villiger and Richard Lewis Maxwell Faull},
  journal={Brain research},
  year={1985},
  volume={345 1},
  pages={196-9}
}
The localization of muscarinic cholinergic receptor subtypes was studied in the human spinal cord using in vitro labelling of cryostat sections with [3H]quinuclidinylbenzilate (QNB) and [3H]pirenzepine (PZ) followed by autoradiography. The highest densities of [3H]QNB binding were localized in laminae II (substantia gelatinosa) and IX (motor neurons); in contrast, the highest density of [3H]PZ binding was localized to lamina II where the binding density was 22-32% higher than in lamina IX… CONTINUE READING

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