Muscarinic cholinergic receptors and the canine model of narcolepsy.

  title={Muscarinic cholinergic receptors and the canine model of narcolepsy.},
  author={Thomas S Kilduff and Scott S. Bowersox and Kenneth I. Kaitin and Tacey L. Baker and Roland D. Ciaranello and William C. Dement},
  volume={9 1 Pt 2},
The role of the muscarinic cholinergic receptor in narcolepsy was examined using radioligand binding to various brain regions of normal and genetically narcoleptic Doberman pinschers. In this multi-litter study, a previous report of a proliferation of muscarinic cholinergic receptors in the brainstem was confirmed, and the concentration of the M2 receptor subtype, in particular, was elevated. This up-regulation of brainstem cholinergic receptors suggests a problem with release of acetylcholine… CONTINUE READING

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