Muscarinic and nicotinic receptors raise intracellular Ca2+ levels in rat carotid body type I cells.

@article{Dasso1997MuscarinicAN,
  title={Muscarinic and nicotinic receptors raise intracellular Ca2+ levels in rat carotid body type I cells.},
  author={L L Dasso and Keith J Buckler and Richard D. Vaughan-Jones},
  journal={The Journal of physiology},
  year={1997},
  volume={498 ( Pt 2)},
  pages={327-38}
}
1. The effects of cholinergic agonists upon intracellular free Ca2+ levels ([Ca2+]i) have been studied in enzymically isolated rat carotid body single type I cells, using indo-1. 2. Acetylcholine (ACh) dose-dependently increased [Ca2+]i in 55% of cells studied (EC50 = 13 microM). These [Ca2+]i rises were partially inhibited by atropine or mecamylamine. 3. Specific nicotinic and muscarinic agonists also elevated [Ca2+]i in a dose-dependent manner (nicotine, EC50 = 15 microM; methacholine, EC50… CONTINUE READING
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