• Corpus ID: 37462203

Muscarinic actions of an N-methyl-N-2-bromoethylamino analog of oxotremorine (BR 401) in the mouse.

  title={Muscarinic actions of an N-methyl-N-2-bromoethylamino analog of oxotremorine (BR 401) in the mouse.},
  author={Bj{\"o}rn Ringdahl and Donald J. Jenden},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={240 2},
  • B. Ringdahl, D. Jenden
  • Published 1 February 1987
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
The pharmacological effects of N-[4-(2-bromoethylmethylamino)-2-butynyl]-2-pyrrolidone (BR 401) were compared in the mouse with those of N-[4-(2-chloroethylmethylamino)-2-butynl]-2-pyrrolidone (BM 123) and oxotremorine. BR 401 was more toxic than oxotremorine and BM 123 when administered i.v. (LD50, 0.7 mumol kg-1), but less toxic than oxotremorine when given i.p. (LD50, 39 mumol kg-1). Atropine and methylatropine (10 mumol kg-1 i.p.) increased the LD50 value of BR 401, given i.v., 75- to 100… 
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