Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development.

  title={Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development.},
  author={Andrew C Kruse and Jianxin Hu and Brian K. Kobilka and Juergen Wess},
  journal={Current opinion in pharmacology},
Muscarinic acetylcholine receptor antagonists are widely used as bronchodilating drugs in pulmonary medicine. The therapeutic efficacy of these agents depends on the blockade of M3 muscarinic receptors expressed on airway smooth muscle cells. All muscarinic antagonists currently used as bronchodilating agents show high affinity for all five muscarinic receptor subtypes, thus increasing the likelihood of unwanted side effects. Recent X-ray crystallographic studies have provided detailed… CONTINUE READING
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