Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in the hippocampal-prefrontal cortex pathway of rats in vivo: a possible involvement of monoaminergic systems.

@article{Aguiar2008MuscarinicAN,
  title={Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in the hippocampal-prefrontal cortex pathway of rats in vivo: a possible involvement of monoaminergic systems.},
  author={C Lopes Aguiar and Rodrigo Neves Romcy-Pereira and R Escorsim Szawka and Orfa Yineth Galvis-Alonso and Janete Aparecida Anselmo-Franci and J. Pereira Leite},
  journal={Neuroscience},
  year={2008},
  volume={153 4},
  pages={1309-19}
}
The prefrontal cortex is continuously required for working memory processing during wakefulness, but is particularly hypoactivated during sleep and in psychiatric disorders such as schizophrenia. Ammon's horn CA1 hippocampus subfield (CA1) afferents provide a functional modulatory path that is subjected to synaptic plasticity and a prominent monoaminergic influence. However, little is known about the muscarinic cholinergic effects on prefrontal synapses. Here, we investigated the effects of the… CONTINUE READING