Muscarinic Receptor Occupancy and Cognitive Impairment: A PET Study with [11C](+)3-MPB and Scopolamine in Conscious Monkeys

@article{Yamamoto2011MuscarinicRO,
  title={Muscarinic Receptor Occupancy and Cognitive Impairment: A PET Study with [11C](+)3-MPB and Scopolamine in Conscious Monkeys},
  author={Shigeyuki Yamamoto and Shingo Nishiyama and Masahiro Kawamata and Hiroyuki Ohba and Tomoyasu Wakuda and Noriyoshi Takei and Hideo Tsukada and Edward F. Domino},
  journal={Neuropsychopharmacology},
  year={2011},
  volume={36},
  pages={1455-1465}
}
The muscarinic cholinergic receptor (mAChR) antagonist scopolamine was used to induce transient cognitive impairment in monkeys trained in a delayed matching to sample task. The temporal relationship between the occupancy level of central mAChRs and cognitive impairment was determined. Three conscious monkeys (Macaca mulatta) were subjected to positron emission tomography (PET) scans with the mAChR radioligand N-[11C]methyl-3-piperidyl benzilate ([11C](+)3-MPB). The scan sequence was pre-, 2, 6… CONTINUE READING
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