Muscarinic Receptor Binding of Imidafenacin in the Human Bladder Mucosa and Detrusor and Parotid Gland.

@article{Seki2011MuscarinicRB,
  title={Muscarinic Receptor Binding of Imidafenacin in the Human Bladder Mucosa and Detrusor and Parotid Gland.},
  author={Masanao Seki and Masaki Ogoda and Shiori Kuraoka and Atsushi Otsuka and Seiichiro Ozono and Masayuki Takeda and Keisuke Masuyama and Kazumichi Matsushita and Shin'ichi Yamada},
  journal={Lower urinary tract symptoms},
  year={2011},
  volume={3 2},
  pages={
          64-8
        }
}
OBJECTIVES The current study aimed to characterize comparatively the binding of imidafenacin to muscarinic receptors in the human bladder mucosa and detrusor muscle and parotid gland. METHODS The muscarinic receptor in homogenates of human tissues (bladder mucosa and detrusor muscle and parotid gland) was measured using a radioligand binding assay with [N-methyl-(3) H]scopolamine methyl chloride ([(3) H]NMS). RESULTS Imidafenacin competed with [(3) H]NMS for binding sites in the bladder… CONTINUE READING
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