Muscarinic M4 receptor inhibition of dopamine D1-like receptor signalling in rat nucleus accumbens.

@article{Onali2002MuscarinicMR,
  title={Muscarinic M4 receptor inhibition of dopamine D1-like receptor signalling in rat nucleus accumbens.},
  author={Pierluigi Onali and Maria C. Olianas},
  journal={European journal of pharmacology},
  year={2002},
  volume={448 2-3},
  pages={105-11}
}
Several studies have indicated the occurrence of an antagonistic interaction between muscarinic and dopamine D1-like receptors in the ventral striatum, but the subtype(s) of muscarinic receptor involved has not been characterized. We show that in membranes of rat nucleus accumbens, carbachol inhibited the stimulation of adenylyl cyclase activity by dopamine and the dopamine D1-like receptor agonist (+/-)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine without… CONTINUE READING