Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle.

@article{Gosens2003MuscarinicMM,
  title={Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle.},
  author={Reinoud Gosens and S. Adriaan Nelemans and Mechteld M Grootte Bromhaar and Sue M McKay and Johan Zaagsma and Herman Meurs},
  journal={American journal of respiratory cell and molecular biology},
  year={2003},
  volume={28 2},
  pages={257-62}
}
Muscarinic receptor agonists have been considered to act synergistically in combination with growth facors on airway smooth muscle growth. Characterization of the proliferative responses and of the receptor subtype(s) involved has not yet been studied. Therefore, we investigated mitogenesis induced by stimulation of muscarinic receptors, alone and in combination with stimulation by platelet-derived growth factor (PDGF). For this purpose, [(3)H]thymidine-incorporation was measured at different… CONTINUE READING
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