Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells.

@article{Gosens2009MuscarinicMR,
  title={Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells.},
  author={Reinoud Gosens and Dani{\"e}lle Rieks and Herman Meurs and Dennis K. Ninaber and Klaus Friedrich Rabe and Johannes Nanninga and Saeed Kolahian and Andrew J Halayko and Pieter S Hiemstra and Suzanne Zuyderduyn},
  journal={The European respiratory journal},
  year={2009},
  volume={34 6},
  pages={1436-43}
}
Acetylcholine is the primary parasympathetic neurotransmitter in the airways and is known to cause bronchoconstriction and mucus secretion. Recent findings suggest that acetylcholine also regulates aspects of remodelling and inflammation through its action on muscarinic receptors. In the present study, we aimed to determine the effects of muscarinic receptor stimulation on cytokine production by human airway smooth muscle cells (primary and immortalised cell lines). The muscarinic receptor… CONTINUE READING

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