Muscarinic M2 receptors mediate transactivation of EGF receptor through Fyn kinase and without matrix metalloproteases.

@article{Stirnweiss2006MuscarinicMR,
  title={Muscarinic M2 receptors mediate transactivation of EGF receptor through Fyn kinase and without matrix metalloproteases.},
  author={J{\"o}rg Stirnweiss and Christina Valkova and Elisabeth Ziesch{\'e} and Sebastian Drube and Claus Liebmann},
  journal={Cellular signalling},
  year={2006},
  volume={18 8},
  pages={1338-49}
}
Transactivation of epidermal growth factor receptor (EGFR) by G protein-coupled receptors (GPCRs) has been attributed to the activation of matrix metalloproteases (MMPs) and the release of EGF family ligands such as HB-EGF. This mode of transactivation leads to signalling downstream of EGFR which is indistinguishable from that induced by the ligand. Here we provide evidence that in the COS-7 cell model EGFR transactivation via the muscarinic M2 receptor (M2R) is independent of MMPs and results… CONTINUE READING

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