Muscarinic M2 receptors in acetylcholine-isoproterenol functional antagonism in human isolated bronchus.

@article{Sarri2002MuscarinicMR,
  title={Muscarinic M2 receptors in acetylcholine-isoproterenol functional antagonism in human isolated bronchus.},
  author={Benjam{\'i}n Sarri{\'a} and Emmanuel Naline and Yong Zhang and Julio Cortijo and Mathi{\'e}u Molimard and Joelle Moreau and Patrice Th{\'e}rond and Charles Advenier and Esteban Jes{\'u}s Morcillo},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={283 5},
  pages={
          L1125-32
        }
}
The muscarinic functional antagonism of isoproterenol relaxation and the contribution of muscarinic M2 receptors were examined in human isolated bronchus. In intact tissues, acetylcholine (ACh) precontraction decreased isoproterenol potency and maximal relaxation (-log EC50 shift = -1.49 +/- 0.16 and E(max) inhibition for 100 microM ACh = 30%) more than the same levels of histamine contraction. The M2 receptor-selective antagonist methoctramine (1 microM) reduced this antagonism in ACh- but not… CONTINUE READING
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