Muscarinic M1 acetylcholine receptors regulate the non-quantal release of acetylcholine in the rat neuromuscular junction via NO-dependent mechanism.

@article{Malomouzh2007MuscarinicMA,
  title={Muscarinic M1 acetylcholine receptors regulate the non-quantal release of acetylcholine in the rat neuromuscular junction via NO-dependent mechanism.},
  author={Artem I. Malomouzh and Marat R Mukhtarov and Eugen E. Nikolsky and Frantisek Vyskocil},
  journal={Journal of neurochemistry},
  year={2007},
  volume={102 6},
  pages={2110-2117}
}
Nitric oxide (NO), previously demonstrated to participate in the regulation of the resting membrane potential in skeletal muscles via muscarinic receptors, also regulates non-quantal acetylcholine (ACh) secretion from rat motor nerve endings. Non-quantal ACh release was estimated by the amplitude of endplate hyperpolarization (H-effect) following a blockade of skeletal muscle post-synaptic nicotinic receptors by (+)-tubocurarine. The muscarinic agonists oxotremorine and muscarine lowered the H… CONTINUE READING
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