Muscarinic M(1) agonists in the treatment of Alzheimer's disease.

@article{Korczyn2000MuscarinicMA,
  title={Muscarinic M(1) agonists in the treatment of Alzheimer's disease.},
  author={Amos D. Korczyn},
  journal={Expert opinion on investigational drugs},
  year={2000},
  volume={9 10},
  pages={2259-67}
}
The treatment of Alzheimer's disease attempts to correct cholinergic deficiency in the brain. In addition to the established, but restricted, efficacy of acetylcholinesterase inhibitors, attempts are being made to develop agents which will stimulate muscarinic receptors directly. This approach is logical and was found efficacious in several animal models of… CONTINUE READING