Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

@inproceedings{Katz2014MusashiPA,
  title={Musashi proteins are post-transcriptional regulators of the
epithelial-luminal cell state},
  author={Yarden Katz and Feifei Li and N. J. Lambert and Ethan S. Sokol and W Tam and Albert Zi Wen Cheng and Edoardo M. Airoldi and Christopher Joachim Lengner and Piyush B. Gupta and Zhengquan Yu and Rudolf Jaenisch and Christopher B. Burge},
  booktitle={eLife},
  year={2014}
}
The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells, consistent with a role in cell state regulation. We found that Msi genes are rarely mutated but frequently overexpressed in human cancers and are associated with an epithelial-luminal cell state. Using ribosome profiling and RNA-seq analysis, we found that Msi proteins regulate translation of genes implicated in epithelial cell biology and… CONTINUE READING
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