Musashi 2 in hematopoiesis

@article{deAndrsAguayo2012Musashi2I,
  title={Musashi 2 in hematopoiesis},
  author={Luisa de Andr{\'e}s-Aguayo and Florencio Varas and Thomas Graf},
  journal={Current Opinion in Hematology},
  year={2012},
  volume={19},
  pages={268–272}
}
Purpose of reviewRecent work has shown that the Musashi 2 (Msi2) gene plays important roles in normal and malignant hematopoiesis. Here, we give an overview on the role of Msi2 in the regulation and function of primitive hematopoietic cells as well as in leukaemic progression. We also discuss the molecular pathways in which Msi2 acts in both normal and leukaemic blood cells. Recent findingsMsi2 gain and loss of function experiments have shown that it plays an important role in regulating the… Expand
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  • W. Sheng, M. Dong, +5 authors Jianping Zhou
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2017
TLDR
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Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
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A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).
TLDR
It is shown that a novel gene in 17q23, Musashi-2 (MSI2), encoding a putative RNA-binding protein, is rearranged in both cases and that a MSI2/HOXA9 fusion gene is formed in the case with the 7p15 breakpoint. Expand
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