Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells

@article{Murayama2008Musashi1SE,
  title={Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells},
  author={Minekazu Murayama and Ryuichi Okamoto and Kiichiro Tsuchiya and Junko Morio Akiyama and Tetsuya Nakamura and Naoya Sakamoto and T. Hosokawa Kanai and Mamoru Watanabe},
  journal={Journal of Gastroenterology},
  year={2008},
  volume={44},
  pages={173-182}
}
Musashi-1 (Msi-1) is a RNA-binding protein, known as a putative marker of intestinal stem cells (ISCs). However, little is known about the function of Msi-1 within human intestinal epithelial cells (IECs). Thus, the present study aimed to clarify the role of Msi-1 in differentiation and proliferation of IECs. A human intestinal epithelial cell line stably expressing Msi-1 was established. Proliferation of the established cell lines was measured by bromodeoxyuridine incorporation, whereas… CONTINUE READING

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