Musashi: a translational regulator of cell fate.

@article{Okano2002MusashiAT,
  title={Musashi: a translational regulator of cell fate.},
  author={Hideyuki Okano and Takao Imai and Masataka Okabe},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 7},
  pages={
          1355-9
        }
}
Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi, for example, controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular… CONTINUE READING

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