Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.

@article{Willis2008Mus81RA,
  title={Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.},
  author={Nicholas A Willis and Nicholas Rhind},
  journal={Molecular biology of the cell},
  year={2008},
  volume={20 3},
  pages={
          819-33
        }
}
The S-phase DNA damage checkpoint slows the rate of DNA synthesis in response to damage during replication. In the fission yeast Schizosaccharomyces pombe, Cds1, the S-phase-specific checkpoint effector kinase, is required for checkpoint signaling and replication slowing; upon treatment with the alkylating agent methyl methane sulfonate, cds1Delta mutants display a complete checkpoint defect. We have identified proteins downstream of Cds1 required for checkpoint-dependant slowing, including the… CONTINUE READING
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Regulation of DNA replication by the S-phase DNA damage checkpoint

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Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

  • Proceedings of the National Academy of Sciences of the United States of America
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