Murine tissue factor gene expression in vivo. Tissue and cell specificity and regulation by lipopolysaccharide.

@article{Mackman1993MurineTF,
  title={Murine tissue factor gene expression in vivo. Tissue and cell specificity and regulation by lipopolysaccharide.},
  author={Nigel Mackman and Merry Sawdey and M R Keeton and David J. Loskutoff},
  journal={The American journal of pathology},
  year={1993},
  volume={143 1},
  pages={
          76-84
        }
}

• Nigel Mackman, Merry Sawdey, +1 author David J. Loskutoff
• Published 1993 in The American journal of pathology

Regulation of tissue factor (TF) gene expression was studied in vivo employing a murine model system. In untreated mice, TF mRNA was detected in brain, lung, kidney, and heart by Northern blot analysis. After administration of lipopolysaccharide, steady-state levels of TF mRNA were unchanged in brain, decreased in heart, and increased in both kidney and lung. In the brain, Bergmann glia within the Purkinje cell layer of the cerebellum and neuroglia within the cerebral cortex expressed TF mRNA… CONTINUE READING

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