Murine scrapie infection causes an abnormal germinal centre reaction in the spleen.

@article{McGovern2004MurineSI,
  title={Murine scrapie infection causes an abnormal germinal centre reaction in the spleen.},
  author={Gillian McGovern and Karen L. Brown and Moira E. Bruce and M Haddad Jeffrey},
  journal={Journal of comparative pathology},
  year={2004},
  volume={130 2-3},
  pages={181-94}
}
Follicular dendritic cells (FDCs) of the lymphoreticular system play a role in the peripheral replication of prion proteins in some transmissible spongiform encephalopathies (TSEs), including experimental murine scrapie models. Disease-specific PrP (PrPd) accumulation occurs in association with the plasmalemma and extracellular space around FDC dendrites, but no specific immunological response has yet been reported in animals affected by TSEs. In the present study, morphology (light… CONTINUE READING