Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2.

@article{Ye2012MurineRA,
  title={Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2.},
  author={Minghao Ye and Jan Wysocki and Francisco Rom{\'a}n Gonz{\'a}lez-Pacheco and Mahmoud Salem and Karla Evora and Laura Garcia-Halpin and Marko Poglitsch and Manfred Schuster and Daniel Batlle},
  journal={Hypertension},
  year={2012},
  volume={60 3},
  pages={730-40}
}
A newly produced murine recombinant angiotensin (Ang)-converting enzyme 2 (ACE2) was characterized in vivo and in vitro. The effects of available ACE2 inhibitors (MLN-4760 and 2 conformational variants of DX600, linear and cyclic) were also examined. When murine ACE2 was given to mice for 4 weeks, a marked increase in serum ACE2 activity was sustainable. In acute studies, mouse ACE2 (1 mg/kg) obliterated hypertension induced by Ang II infusion by rapidly decreasing plasma Ang II. These effects… CONTINUE READING

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